Terfenadine is metabolized to ________ by _______.

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Multiple Choice

Terfenadine is metabolized to ________ by _______.

Explanation:
Terfenadine is a prodrug that requires hepatic metabolism to become active. The enzyme CYP3A4 converts terfenadine into fexofenadine, the active antihistamine. This metabolic step explains why terfenadine can cause serious QT prolongation if CYP3A4 is inhibited (leading to elevated terfenadine levels). The correct pairing reflects this conversion to fexofenadine by CYP3A4. The other options misidentify either the metabolite or the enzyme, or wrongly imply terfenadine itself is formed by metabolism.

Terfenadine is a prodrug that requires hepatic metabolism to become active. The enzyme CYP3A4 converts terfenadine into fexofenadine, the active antihistamine. This metabolic step explains why terfenadine can cause serious QT prolongation if CYP3A4 is inhibited (leading to elevated terfenadine levels). The correct pairing reflects this conversion to fexofenadine by CYP3A4. The other options misidentify either the metabolite or the enzyme, or wrongly imply terfenadine itself is formed by metabolism.

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