Terfenadine causes _______ _______, leading to __________, by inhibiting Erb channels for ion transport in the heart.

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Prepare for the Adverse Effects and Toxicology Test with our comprehensive format. Utilize flashcards and multiple-choice questions, complete with hints and explanations to ace your exam!

Multiple Choice

Terfenadine causes _______ _______, leading to __________, by inhibiting Erb channels for ion transport in the heart.

Explanation:
Terfenadine can cause prolongation of the QT interval by blocking the hERG potassium channels (IKr) in ventricular myocardium, which delays repolarization. This QTc prolongation increases the risk of torsades de pointes, a dangerous polymorphic ventricular tachycardia that can degenerate into ventricular fibrillation. That sequence—QTc prolongation leading to torsades de pointes—is the key toxicology pattern here. Other options describe different arrhythmias or omit the QT prolongation mechanism, which doesn’t fit the drug’s well-known effect.

Terfenadine can cause prolongation of the QT interval by blocking the hERG potassium channels (IKr) in ventricular myocardium, which delays repolarization. This QTc prolongation increases the risk of torsades de pointes, a dangerous polymorphic ventricular tachycardia that can degenerate into ventricular fibrillation. That sequence—QTc prolongation leading to torsades de pointes—is the key toxicology pattern here. Other options describe different arrhythmias or omit the QT prolongation mechanism, which doesn’t fit the drug’s well-known effect.

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