Meperidine is metabolized to __________, which has less ______ and is more ______.

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Prepare for the Adverse Effects and Toxicology Test with our comprehensive format. Utilize flashcards and multiple-choice questions, complete with hints and explanations to ace your exam!

Multiple Choice

Meperidine is metabolized to __________, which has less ______ and is more ______.

Explanation:
Meperidine is converted in the liver to normeperidine. This metabolite provides little analgesic effect compared with the parent drug and, importantly, can accumulate and cause CNS toxicity. The neurotoxic effects include tremors, myoclonus, agitation, and seizures, especially in patients with renal impairment or after prolonged use. So the correct statement is that meperidine is metabolized to normeperidine, which has less analgesic activity and is neurotoxic.

Meperidine is converted in the liver to normeperidine. This metabolite provides little analgesic effect compared with the parent drug and, importantly, can accumulate and cause CNS toxicity. The neurotoxic effects include tremors, myoclonus, agitation, and seizures, especially in patients with renal impairment or after prolonged use. So the correct statement is that meperidine is metabolized to normeperidine, which has less analgesic activity and is neurotoxic.

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