Cytochrome _______ is the bad pathway for acetaminophen metabolism, resulting in _______ which is a toxic metabolite.

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Multiple Choice

Cytochrome _______ is the bad pathway for acetaminophen metabolism, resulting in _______ which is a toxic metabolite.

Explanation:
Cytochrome P450 enzymes can oxidize acetaminophen to a reactive metabolite called NAPQI. This route is considered the harmful pathway because NAPQI is highly reactive and can bind to cellular proteins, leading to liver injury. Under normal dosing, NAPQI is promptly detoxified by conjugation with glutathione and excreted. When glutathione stores are depleted—such as in an overdose—NAPQI accumulates and causes hepatotoxicity. So the problematic pathway is the P450-mediated formation of NAPQI.

Cytochrome P450 enzymes can oxidize acetaminophen to a reactive metabolite called NAPQI. This route is considered the harmful pathway because NAPQI is highly reactive and can bind to cellular proteins, leading to liver injury. Under normal dosing, NAPQI is promptly detoxified by conjugation with glutathione and excreted. When glutathione stores are depleted—such as in an overdose—NAPQI accumulates and causes hepatotoxicity. So the problematic pathway is the P450-mediated formation of NAPQI.

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