APAP overdose is _______ per day. It leads to _______ toxicity due to the production of _________.

Unlock all questions

This demo includes only 20 questions. Upgrade to access hundreds of questions, flashcards, exam simulations, and disable ads.

Full question bankExam simulationsFlashcards
From $25.99Unlock all

Prepare for the Adverse Effects and Toxicology Test with our comprehensive format. Utilize flashcards and multiple-choice questions, complete with hints and explanations to ace your exam!

Multiple Choice

APAP overdose is _______ per day. It leads to _______ toxicity due to the production of _________.

Explanation:
The main idea is how acetaminophen (APAP) is metabolized and why an overdose damages the liver. Most APAP is safely cleared by conjugation (glucuronidation and sulfation), but when intake exceeds about 4 g in a day, these pathways saturate and more APAP is shunted toward cytochrome P450 enzymes, producing a reactive metabolite called NAPQI. NAPQI is normally kept in check by glutathione, which detoxifies it. In overdose, glutathione stores are depleted, allowing NAPQI to bind to hepatic proteins and cause hepatocellular injury, leading to liver toxicity. That’s why the correct statement is that APAP overdose is greater than 4 g per day, leading to liver toxicity due to production of NAPQI.

The main idea is how acetaminophen (APAP) is metabolized and why an overdose damages the liver. Most APAP is safely cleared by conjugation (glucuronidation and sulfation), but when intake exceeds about 4 g in a day, these pathways saturate and more APAP is shunted toward cytochrome P450 enzymes, producing a reactive metabolite called NAPQI. NAPQI is normally kept in check by glutathione, which detoxifies it. In overdose, glutathione stores are depleted, allowing NAPQI to bind to hepatic proteins and cause hepatocellular injury, leading to liver toxicity. That’s why the correct statement is that APAP overdose is greater than 4 g per day, leading to liver toxicity due to production of NAPQI.

More Multiple Choice Questions
Subscribe

Get the latest from Passetra

You can unsubscribe at any time. Read our privacy policy